When are Uncontrolled Trials in TB Scientifically and Ethically Justified: Borrowing Wisdom From Early AIDS Clinical Trials
Lindsay McKenna, Mike Frick, Valentina A Alarcón-Guizado, Geraint R Davies, Jennifer J Furin, Lorenzo Guglielmetti, Norbert Heinrich, Marcus Low, Mariama Mahmoud, Vidya Mave, Norbert Ndjeka, Patrick P J Phillips, Samuel Schumacher, Mark Harrington, Carole D Mitnick · 2026
Read When are Uncontrolled Trials in TB Scientifically and Ethically Justified: Borrowing Wisdom From Early AIDS Clinical Trials by Lindsay McKenna, Mike Frick, Valentina A Alarcón-Guizado, Geraint R Davies, Jennifer J Furin, Lorenzo Guglielmetti, Norbert Heinrich, Marcus Low, Mariama Mahmoud, Vidya Mave, Norbert Ndjeka, Patrick P J Phillips, Samuel Schumacher, Mark Harrington, Carole D Mitnick (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13537119.txt.
Description
Lindsay McKenna and co-authors ask when tuberculosis treatment trials may run without a control group, borrowing lessons from early AIDS trials. Writing in 2026, the team applies an existing framework for judging such designs to new TB drug plans. They conclude that the needed conditions are not met for TB treatment. Uncontrolled phase three trials, they argue, should not be performed for this disease.
Catalog record
| CREATOR | Lindsay McKenna, Mike Frick, Valentina A Alarcón-Guizado, Geraint R Davies, Jennifer J Furin, Lorenzo Guglielmetti, Norbert Heinrich, Marcus Low, Mariama Mahmoud, Vidya Mave, Norbert Ndjeka, Patrick P J Phillips, Samuel Schumacher, Mark Harrington, Carole D Mitnick |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 20 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |