Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane · 2026
Read Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer by Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13536839.txt.
Description
When ribosomes, the cell's protein builders, stall and crash into each other, the cell treats it as an alarm. Anastassiya Kim and co-authors review that alarm system, the ribotoxic stress response. Triggers range from ultraviolet light and poisons to errors in protein production. The response runs through a sensor kinase, ZAK-alpha, which switches on two stress pathways, p38 and JNK, that steer the cell's moves.
The review sets this response apart from the integrated stress response and maps where it acts across cell life. New work ties it to cancer: some chemotherapy drugs kill tumor cells by forcing this kind of ribosome stress. The authors weigh the limits of that strategy, since normal cells share the same alarm. They close with open questions and ideas for aiming the response more precisely at tumors. Overall, they present the pathway as a promising front in cancer research.
Catalog record
| CREATOR | Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 54 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |