Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen · 2026
Read Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2 by Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13536838.txt.
Description
Joyeeta Chatterjee and co-authors report in 2026 that advanced prostate cancer leans hard on one cell-cycle driver. The driver, called CDK2, helps cells divide. When prostate tumors stop responding to hormone care, their CDK2 activity rises while other drivers fall. That shift leaves the cells hooked on CDK2.
Drugs that block CDK2 slowed the growth of both early and advanced tumor cells. The team also built cells that resist the blocker and screened drugs to pair with it. Hormone drugs and some chemo drugs worked well with the blocker, as did radiation. Pairing may give doctors more ways to treat stubborn cases.
Catalog record
| CREATOR | Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 61 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |