Mitochondria-associated endoplasmic reticulum membrane (MAM): roles in innate immunity dysregulation
Qingqi Zhang, Junyan Gao, Yiting Yang, Ping Guo, Huiqin Gao, Shuaiyong Zhao, Shuanglin Zhang, Yaping Shi, Guanxing Xie, Yutong Han, Hao Liu, Yunzeng Zou · 2026
Read Mitochondria-associated endoplasmic reticulum membrane (MAM): roles in innate immunity dysregulation by Qingqi Zhang, Junyan Gao, Yiting Yang, Ping Guo, Huiqin Gao, Shuaiyong Zhao, Shuanglin Zhang, Yaping Shi, Guanxing Xie, Yutong Han, Hao Liu, Yunzeng Zou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13536812.txt.
Description
Qingqi Zhang and colleagues review contact zones between two cell structures and their role in innate immunity in a 2026 synthesis. The zones link the endoplasmic reticulum and mitochondria, acting as hubs for calcium balance, fat handling, energy control, and cleanup of damaged parts. The review gathers evidence on how those jobs steer first-line immune defenses and what happens when the zones break down.
Healthy zones help tune inflammation alarms and antiviral signaling, while faulty zones leak mitochondrial material that keeps alarms switched on. Immune activation can in turn damage the zones, creating a self-feeding cycle tied to autoimmune disease. The authors highlight control points within the zones as possible drug targets for calming overactive innate immunity without shutting defense down entirely.
Catalog record
| CREATOR | Qingqi Zhang, Junyan Gao, Yiting Yang, Ping Guo, Huiqin Gao, Shuaiyong Zhao, Shuanglin Zhang, Yaping Shi, Guanxing Xie, Yutong Han, Hao Liu, Yunzeng Zou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55605 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |