The circadian architecture of tumor immunity: mechanistic insights and treatment strategies
Hao Wang, Bin Guo, Danfeng Li, Yuxi Liu, Kun Cheng, Wanguang Zhang, Huifang Liang · 2026
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Description
Hao Wang and co-authors review how daily body clocks shape tumor immunity in a 2026 synthesis. Clocks in the brain, in single cells, and in daily habits such as sleep and meals jointly time cell growth, energy use, and immune activity. Disrupted clocks have been linked to higher cancer risk and poorer outcomes. The review connects clock disruption to changes in the tissue around tumors.
Disruption weakens immune watchfulness and reshapes both innate and adaptive defenses, helping tumors start and grow. Clock signals govern how killer cells, helper cells, and suppressor cells develop, move, and act. Proposed responses include timing treatments to the clock and pairing clock-targeted steps with immunotherapy. The authors present clock-aware care as a route to sharper, stronger cancer treatment.
Catalog record
| CREATOR | Hao Wang, Bin Guo, Danfeng Li, Yuxi Liu, Kun Cheng, Wanguang Zhang, Huifang Liang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 147 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |