Autophagy-promoted immunogenic cell death elicited by tyrosine kinase inhibitor orchestrates a synergistic immunotherapeutic microenvironment in hepatocellular carcinoma
Shan-Ru Feng, En-Fu Dong, Zheng Gao, Mo-Ran Xu, Pascal Kwangwari, Cheng-Qiang Sun, Jia‑Feng Chen, Ying‑Hong Shi, Wei‑Ren Liu, Wei‑Xun Wu, Xin Zhang, Ao Huang, Xuan‑Ming Luo, Qiang Gao, Guo‑Ming Shi, Ai‑Wu Ke, Jian Zhou, Jia Fan, Xiao-ying Wang, Jing-Bo Qie, Xiu‑Tao Fu, Zhen‑Bin Ding · 2026
Read Autophagy-promoted immunogenic cell death elicited by tyrosine kinase inhibitor orchestrates a synergistic immunotherapeutic microenvironment in hepatocellular carcinoma by Shan-Ru Feng, En-Fu Dong, Zheng Gao, Mo-Ran Xu, Pascal Kwangwari, Cheng-Qiang Sun, Jia‑Feng Chen, Ying‑Hong Shi, Wei‑Ren Liu, Wei‑Xun Wu, Xin Zhang, Ao Huang, Xuan‑Ming Luo, Qiang Gao, Guo‑Ming Shi, Ai‑Wu Ke, Jian Zhou, Jia Fan, Xiao-ying Wang, Jing-Bo Qie, Xiu‑Tao Fu, Zhen‑Bin Ding (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13536651.txt.
Description
Shan-Ru Feng and colleagues screen in 2026 cancer drugs to find one that makes liver tumours die in a way that wakes up the immune system. Most liver cancers stay cold to immune therapy, with low response rates to standard drug pairs. Cell, tissue, and mouse tests compared several kinase-blocking drugs for immune-style death signals.
Anlotinib stood out, releasing alarm signals from dying tumour cells through cell stress and self-eating pathways. Treated tissue drew in and switched on immune defender cells, which then primed killer T cells. The work sets up a pairing strategy for immune drugs in liver cancer.
Catalog record
| CREATOR | Shan-Ru Feng, En-Fu Dong, Zheng Gao, Mo-Ran Xu, Pascal Kwangwari, Cheng-Qiang Sun, Jia‑Feng Chen, Ying‑Hong Shi, Wei‑Ren Liu, Wei‑Xun Wu, Xin Zhang, Ao Huang, Xuan‑Ming Luo, Qiang Gao, Guo‑Ming Shi, Ai‑Wu Ke, Jian Zhou, Jia Fan, Xiao-ying Wang, Jing-Bo Qie, Xiu‑Tao Fu, Zhen‑Bin Ding |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75140 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |