Association between voltage-gated sodium channel gene polymorphisms and chronic oxaliplatin-induced peripheral neuropathy in Japanese patients with colorectal cancer
Masato Matsuura, Ayumu Nagamine, Takashi Masuno, Akira Tabei, Teruko Nasaka, Hiromi Nishiba, Maho Koike, Yuta Takahashi, Kyoko Obayashi · 2026
Read Association between voltage-gated sodium channel gene polymorphisms and chronic oxaliplatin-induced peripheral neuropathy in Japanese patients with colorectal cancer by Masato Matsuura, Ayumu Nagamine, Takashi Masuno, Akira Tabei, Teruko Nasaka, Hiromi Nishiba, Maho Koike, Yuta Takahashi, Kyoko Obayashi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13536608.txt.
Description
Masato Matsuura and colleagues test in 2026 whether variants in sodium channel genes track chronic nerve damage from the cancer drug oxaliplatin in Japanese patients. Such gene links were unclear in this group. Seventy-six patients with colorectal cancer who had oxaliplatin-based treatment gave samples and symptom scores.
One variant in the SCN4A gene linked to lower symptom burden both at treatment end and six months later. Another variant showed a weaker, short-lived link the other way. The authors call the lead variant a candidate marker, pending checks in larger groups.
Catalog record
| CREATOR | Masato Matsuura, Ayumu Nagamine, Takashi Masuno, Akira Tabei, Teruko Nasaka, Hiromi Nishiba, Maho Koike, Yuta Takahashi, Kyoko Obayashi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 37100 |
| LICENSE | https://creativecommons.org/publicdomain/zero/1.0 |
| RIGHTS | CC0 |
| SOURCE | Europe PMC |