A new and efficient synthesis of substituted 2-amino-1,3,4-oxadiazoles from isothiocyanates and hydrazides
Lei Wu, Haiyign Tian, Yuying Zhang, Wenjing Ma, Qi Zhang, Ruiling Chen, Xiuling Chen · 2026
Read A new and efficient synthesis of substituted 2-amino-1,3,4-oxadiazoles from isothiocyanates and hydrazides by Lei Wu, Haiyign Tian, Yuying Zhang, Wenjing Ma, Qi Zhang, Ruiling Chen, Xiuling Chen (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13536576.txt.
Description
Lei Wu and colleagues report in 2026 a simple new route to substituted 2-amino-1,3,4-oxadiazoles from hydrazides and isothiocyanates. These ring compounds matter widely in drug and farm chemical research, so easier synthesis has broad value. The method uses sodium hydroxide to drive a ring-closing step that removes sulfur under mild conditions.
The team reports wide substrate tolerance, strong yields, and easy handling across many variants. Such direct access could speed library building for biological screening in medicine and crop science. An alternative regioselective path to this valued scaffold is now open to chemists.
Catalog record
| CREATOR | Lei Wu, Haiyign Tian, Yuying Zhang, Wenjing Ma, Qi Zhang, Ruiling Chen, Xiuling Chen |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 17477 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |