A Novel Blood‐Based Screening Test for Colorectal Cancer Using Raman Spectroscopy
Jett Karolewski, Georgia Carroll, Rosemary Carroll, Rodney J. Scott, Stephen Smith, Joel Petit · 2026
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Description
Karolewski and co-authors test a blood test for bowel cancer built on light scattering rather than stool samples, which many Australians skip despite free screening kits. Raman spectroscopy reads the molecular vibration fingerprint of blood plasma, and machine learning hunts for the cancer pattern inside it. Their 2026 exploratory study analysed plasma from 370 people: 117 with colorectal cancer and 253 controls. The controls had tested positive on the stool test but proved to have adenomas, inflammation, or healthy colons.
Split into training and validation sets, the model caught the large majority of cancers in the untouched validation group. It correctly cleared most controls, at accuracy levels the authors call high for a screening candidate. Projected onto practice, nearly all cancer patients would still reach colonoscopy, while about two fifths of stool-positive people might be spared an unnecessary one.
Catalog record
| CREATOR | Jett Karolewski, Georgia Carroll, Rosemary Carroll, Rodney J. Scott, Stephen Smith, Joel Petit |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 19 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |