59 GPNMB:CD44 Signaling Drives Tumor Progression in Translocation Renal Cell Carcinoma
Kaushal Asrani, Juhyung Woo, Thiago Vidotto, Kewen Feng, Adrianna Amaral, Vikrant Palande, Jayaprakash Mandal, Eddie Imada, Christopher Thoburn, Sangeeta Ray, Huili Li, Pornima Phatak, James Donahue, Yasser Ged, Nirmish Singla, John Copland, Laura Schmidt, Marston Linehan, Pedram Argani, Tamara Lota · 2026
Read 59 GPNMB:CD44 Signaling Drives Tumor Progression in Translocation Renal Cell Carcinoma by Kaushal Asrani, Juhyung Woo, Thiago Vidotto, Kewen Feng, Adrianna Amaral, Vikrant Palande, Jayaprakash Mandal, Eddie Imada, Christopher Thoburn, Sangeeta Ray, Huili Li, Pornima Phatak, James Donahue, Yasser Ged, Nirmish Singla, John Copland, Laura Schmidt, Marston Linehan, Pedram Argani, Tamara Lota (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13535389.txt.
Description
Kaushal Asrani and co-authors present a 2026 study on a protein pair that drives a rare kidney cancer. The cancer, called tRCC, starts from gene fusions and often strikes children. Few markers or targeted drugs exist for it. One protein, GPNMB, runs high in these tumors and links to poor outcomes.
GPNMB is switched on by the same gene family that the fusions disturb. The team shows it signals through a partner protein, CD44, to push tumor growth. Blocking that pair could give this cancer its first aimed treatment. The work also names a marker that may help doctors spot the disease.
Catalog record
| CREATOR | Kaushal Asrani, Juhyung Woo, Thiago Vidotto, Kewen Feng, Adrianna Amaral, Vikrant Palande, Jayaprakash Mandal, Eddie Imada, Christopher Thoburn, Sangeeta Ray, Huili Li, Pornima Phatak, James Donahue, Yasser Ged, Nirmish Singla, John Copland, Laura Schmidt, Marston Linehan, Pedram Argani, Tamara Lota |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 4 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |