Proteome analyses reveal endoplasmic reticulum stress-induced changes in protein abundance associated with Ube2j2 deficiency in human cell culture
Caroline L Dahlberg, Matthew Zinkgraf, Sophie Heiden Laugesen, Cecile Lützen Søltoft, Queralt Ginebra, Eric Paul Bennett, Rasmus Hartmann-Petersen, Lars Ellgaard · 2026
Read Proteome analyses reveal endoplasmic reticulum stress-induced changes in protein abundance associated with Ube2j2 deficiency in human cell culture by Caroline L Dahlberg, Matthew Zinkgraf, Sophie Heiden Laugesen, Cecile Lützen Søltoft, Queralt Ginebra, Eric Paul Bennett, Rasmus Hartmann-Petersen, Lars Ellgaard (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13535379.txt.
Description
Caroline Dahlberg and co-authors delete one enzyme from human cells and watch the whole protein economy reorganize under stress. Ube2j2 helps the endoplasmic reticulum destroy misfolded proteins, part of the unfolded protein response. Mass spectrometry profiled cultured bone tumor cells, with and without the enzyme, as a drug flooded their reticulum with bad proteins.
The abundance patterns fell into twelve modules, each summarized by its most typical member and its biological annotations. Familiar pathways tied to the enzyme lit up, protein quality control above all. So did functions nobody had connected to it: RNA metabolism, transport between reticulum and Golgi, and cell-cycle progression. The authors deposit the data publicly and offer the map as a set of leads for what this enzyme quietly does all day.
Catalog record
| CREATOR | Caroline L Dahlberg, Matthew Zinkgraf, Sophie Heiden Laugesen, Cecile Lützen Søltoft, Queralt Ginebra, Eric Paul Bennett, Rasmus Hartmann-Petersen, Lars Ellgaard |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |