75 Transcriptional Correlates of ARNT Expression and its Impact on Survival Outcomes in Clear-Cell Renal Cell Carcinoma (ccRCC)
Wassim Daoud Khatoun, Ali Hajj Ali, Eddy Saad, Mustafa Saleh, Jad El Masri, Pablo Barrios, Chris Labaki, Harry Kane, Kevin Meli, Renee Maria Saliby, Ro Malik, Sabina Signoretti, David McDermott, Rana McKay, Eli Van Allen, David Braun, Toni Choueiri · 2026
Read 75 Transcriptional Correlates of ARNT Expression and its Impact on Survival Outcomes in Clear-Cell Renal Cell Carcinoma (ccRCC) by Wassim Daoud Khatoun, Ali Hajj Ali, Eddy Saad, Mustafa Saleh, Jad El Masri, Pablo Barrios, Chris Labaki, Harry Kane, Kevin Meli, Renee Maria Saliby, Ro Malik, Sabina Signoretti, David McDermott, Rana McKay, Eli Van Allen, David Braun, Toni Choueiri (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13535369.txt.
Description
The authors study a gene called ARNT and its links to survival in the most common kidney cancer, in a 2026 analysis. The gene makes a partner protein that switches on low-oxygen response paths, including paths that grow new blood vessels. The team asked how the gene’s activity tracks with low-oxygen and immune programs inside tumors.
They pooled tumor gene data from a large atlas set of 529 patients across all stages. They added data from two first-line drug trials in spread kidney cancer, with 741 and 403 patients, comparing a vessel-blocking drug alone against the drug plus immune therapy. By matching gene activity to outcomes, they test whether ARNT marks patients who fare better or worse on each care plan.
Catalog record
| CREATOR | Wassim Daoud Khatoun, Ali Hajj Ali, Eddy Saad, Mustafa Saleh, Jad El Masri, Pablo Barrios, Chris Labaki, Harry Kane, Kevin Meli, Renee Maria Saliby, Ro Malik, Sabina Signoretti, David McDermott, Rana McKay, Eli Van Allen, David Braun, Toni Choueiri |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |