Evolutionary Response Patterns of the Rodent TLR Genes to Climatic Factors
Chao Zhao, Tian Xia, Guangshuai Liu, Zhao Liu, Xinglei Ding, Shuo Dai, Honghai Zhang · 2026
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Description
Chao Zhao and co-authors ask whether climate has steered the evolution of rodent immune genes. Toll-like receptors spot invaders and start the innate immune defense, and their change over time ties to pathogen pressure. The team pulled nine such genes from forty-two rodent species with narrow home ranges and compared their evolution rates against ten climate measures.
Each gene answered to climate in its own way. Rain-linked factors tracked with faster change in the TLR2 and TLR4 genes. A temperature swing measure, the mean diurnal range, tracked with TLR8 and TLR9 instead. The authors reason that rain and heat reshape the pathogen mix each species faces, which in turn pushes its sensors to adapt. The study links weather to immunity through deep time.
Catalog record
| CREATOR | Chao Zhao, Tian Xia, Guangshuai Liu, Zhao Liu, Xinglei Ding, Shuo Dai, Honghai Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 42 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |