Investigating the Contribution of Molecular‐Enriched Functional Connectivity to Brain‐Age Analysis
Marco Pinamonti, Manuela Moretto, Valentina Sammassimo, Marco Castellaro, Mattia Veronese · 2026
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Description
Marco Pinamonti and Manuela Moretto lead a team that asks if brain connectivity enriched with neurotransmitter maps can predict a person's age better than wiring alone. Their study came out in two thousand twenty-six. Brain age scores stand in for biological aging, but standard models lean on anatomy. A molecular layer could add biological detail that anatomy lacks.
They used data from over two thousand healthy adults in three public sets. Their connectivity maps were enriched with templates for the dopamine, norepinephrine, and serotonin transporter systems. One transporter map alone explained up to about half the variance in age. All three maps together beat any one map each time. Anatomy was still the best single source. Work across sites called for harmonization care, tested both ways. Dopamine led in the strictest tests. The team argues this enrichment adds biological meaning, not just accuracy.
Catalog record
| CREATOR | Marco Pinamonti, Manuela Moretto, Valentina Sammassimo, Marco Castellaro, Mattia Veronese |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 75 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |