Transcriptional Reprogramming of GPCR Signaling Pathways in the Frontal Cortex of Morphine Dependent Mice
Mijin Kim, Sohyeon Moon, Taddesse Yayeh, Thea Villa, Seikwan Oh · 2026
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Description
Mijin Kim, Sohyeon Moon, Taddesse Yayeh, Thea Villa, and Seikwan Oh profile gene shifts in the front brain of morphine dependent mice in 2026. Repeat morphine use for pain often breeds dependence. The team read gene activity after single and long dosing. A set of receptor genes rose under both regimes. Sorting pointed to membrane parts and receptor signal paths.
One gene switch protein lit up during drug withdrawal. That switch drives gene programs tied to adaptation. Behavior tests confirmed strong physical and mental dependence. Two receptors, for dopamine and adenosine, sit at the hub of the shifts. The authors offer the map as a base for targeted anti dependence drugs.
Catalog record
| CREATOR | Mijin Kim, Sohyeon Moon, Taddesse Yayeh, Thea Villa, Seikwan Oh |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |