Expression of tardigrade extremotolerance-associated proteins improves recovery but not acute stress response of human microvascular endothelial cells
William Darch, Janna Soliman, Nicholas C Higgins, Joshua T Morgan · 2026
Read Expression of tardigrade extremotolerance-associated proteins improves recovery but not acute stress response of human microvascular endothelial cells by William Darch, Janna Soliman, Nicholas C Higgins, Joshua T Morgan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13534718.txt.
Description
William Darch and colleagues test in 2026 whether proteins from tardigrades, tiny animals famed for surviving extremes, can help human blood vessel cells handle stress. Vessel lining cells face heat and salt stress in culture and in engineered tissue. Four tardigrade proteins were added to the cells through gene transfer.
During stress itself, cell activity fell in protein-bearing cells. After a recovery day, most protein groups rebounded far above control levels for both salt and heat stress. Protection thus appears context linked, aiding recovery more than the acute phase, which invites deeper study.
Catalog record
| CREATOR | William Darch, Janna Soliman, Nicholas C Higgins, Joshua T Morgan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 33470 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |