Targeting hormone treatment for the brain in menopause
Noriko Itoh, Yuichiro Itoh, Rajita Patil, Christi Till, Marissa Smith, Jaclyn Schwartz, Brittany Davis, Erica Oberman, Brianne D Romeroso, Rhonda R Voskuhl · 2026
Read Targeting hormone treatment for the brain in menopause by Noriko Itoh, Yuichiro Itoh, Rajita Patil, Christi Till, Marissa Smith, Jaclyn Schwartz, Brittany Davis, Erica Oberman, Brianne D Romeroso, Rhonda R Voskuhl (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13534712.txt.
Description
Noriko Itoh leads a team of ten authors who test whether a hormone mix made for menopause can clear the cognitive fog many women report. Estrogens protect the brain. Estriol, which mainly activates one estrogen receptor, in past work improved processing speed and slowed cortex shrinkage in women with multiple sclerosis. Twenty menopausal women took the estriol-progesterone blister pack for a year.
At twelve months the women reported clear gains in brain fog, focus, working memory, processing speed, and verbal memory. A mouse arm showed how it works. Midlife females lost cognitive ground after ovary removal, with glia switching on and synaptic loss in the hippocampus, and a glucose-use enzyme rose in astrocytes as scores worsened. Deleting the receptor in astrocytes copied the harm of ovary removal.
Catalog record
| CREATOR | Noriko Itoh, Yuichiro Itoh, Rajita Patil, Christi Till, Marissa Smith, Jaclyn Schwartz, Brittany Davis, Erica Oberman, Brianne D Romeroso, Rhonda R Voskuhl |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 68 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |