CaMKIIα mediates feedback effects of wheel-running activity on the circadian pacemaker in mice
Tomoko Yoshikawa, Ken-ichi Honma, Isao Tokuda, Sato Honma · 2026
Read CaMKIIα mediates feedback effects of wheel-running activity on the circadian pacemaker in mice by Tomoko Yoshikawa, Ken-ichi Honma, Isao Tokuda, Sato Honma (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13534668.txt.
Description
Tomoko Yoshikawa and three co-authors show how running feeds back on the body clock in mice. Their 2026 study centers on a protein switch called CaMKIIα. Mice lacking its working form entrained oddly to short days. Normal mice locked onto lights-off; mutants locked onto lights-on instead.
Under constant darkness, the clock period split by genotype and wheel access. Without wheels, the two groups' periods converged. Restoring wheels restored the old patterns in both. Activity spans shifted the same way. A two-oscillator model with the protein in the coupling reproduced the effects. Exercise, it seems, talks back to the clock through this switch.
Catalog record
| CREATOR | Tomoko Yoshikawa, Ken-ichi Honma, Isao Tokuda, Sato Honma |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 39 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |