6-gingerol attenuates renal interstitial fibrosis by downregulating PI3K/Akt/mTOR signaling pathway in unilateral ureteral obstruction rats
Vivian Soetikno, Nouman Ahmad, Maritza Gantari Makhrus, Farah Fauzika Haikal, Muhammad Ali Rashidin, Abdullah Ahmad Shiddiq, Iskandar Budianto, Vetriselvan Subramaniyan · 2026
Read 6-gingerol attenuates renal interstitial fibrosis by downregulating PI3K/Akt/mTOR signaling pathway in unilateral ureteral obstruction rats by Vivian Soetikno, Nouman Ahmad, Maritza Gantari Makhrus, Farah Fauzika Haikal, Muhammad Ali Rashidin, Abdullah Ahmad Shiddiq, Iskandar Budianto, Vetriselvan Subramaniyan (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13534457.txt.
Description
Vivian Soetikno and colleagues test in 2026 whether 6-gingerol, a natural compound from ginger, can ease kidney scarring in rats with a blocked ureter. Scarring is a main path to kidney failure, driven by oxidative stress and a growth signalling pathway. Rats with a tied ureter for 14 days received the compound or no treatment.
Treated rats showed less scarring and less collagen build-up in the blocked kidney. Activity of the growth pathway fell, scarring genes quieted, and antioxidant defence rose while a damage marker fell. Readers see a natural candidate worth testing further for kidney protection.
Catalog record
| CREATOR | Vivian Soetikno, Nouman Ahmad, Maritza Gantari Makhrus, Farah Fauzika Haikal, Muhammad Ali Rashidin, Abdullah Ahmad Shiddiq, Iskandar Budianto, Vetriselvan Subramaniyan |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 32847 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |