Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma
Yi Shuai, Hualiang Yao, Bo Wang, Grace T.Y. Chung, Xiangeng Wang, Ming Zhong, Zhongxu Zhu, Cheuk Shuen Li, Chi Man Tsang, Kwok-Wai Lo, Xin Wang · 2026
Read Long-read sequencing reveals widespread novel splicing and neojunction-derived neoantigens in nasopharyngeal carcinoma by Yi Shuai, Hualiang Yao, Bo Wang, Grace T.Y. Chung, Xiangeng Wang, Ming Zhong, Zhongxu Zhu, Cheuk Shuen Li, Chi Man Tsang, Kwok-Wai Lo, Xin Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13534237.txt.
Description
Yi Shuai and ten co-authors map gene splicing in a throat cancer in 2026 with long-read sequencing. Nasopharyngeal cancer arises behind the nose, and its splicing patterns were barely charted. Splicing variety feeds cancer traits and can create new targets for immune therapy.
Long reads from fourteen tumors and four lab cell lines yielded over twenty-two thousand new transcript forms, about forty-four percent of all found. Some new forms ran higher in tumors than in normal-like cells. Fused transcripts appeared too. A custom tool then predicted immune targets born at fresh splice joints, and lab tests confirmed some could stir an immune response.
Catalog record
| CREATOR | Yi Shuai, Hualiang Yao, Bo Wang, Grace T.Y. Chung, Xiangeng Wang, Ming Zhong, Zhongxu Zhu, Cheuk Shuen Li, Chi Man Tsang, Kwok-Wai Lo, Xin Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 63 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |