Immune Dysregulation in Down Syndrome: Implications for Infectious Susceptibility and Vaccine Response
Sofía Solari-Hernández, Enrique González-Madrid, Pablo A González, Susan M Bueno, Alexis M Kalergis · 2026
Read Immune Dysregulation in Down Syndrome: Implications for Infectious Susceptibility and Vaccine Response by Sofía Solari-Hernández, Enrique González-Madrid, Pablo A González, Susan M Bueno, Alexis M Kalergis (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13534213.txt.
Description
Sofia Solari-Hernandez and colleagues review in 2026 immune problems in Down syndrome, a condition caused by an extra copy of chromosome 21. Extra gene copies over-activate interferon signals, a core immune alarm, and keep inflammation switched on. Both first-line and targeted immune defences show faults in cell numbers and function.
Clinically, people face higher risk of severe lung infections and weaker, shorter vaccine responses. Studies report more hospital care and deaths plus faster fading of antibody levels after vaccines. Readers gain a frame for tailoring prevention and vaccine plans for this group.
Catalog record
| CREATOR | Sofía Solari-Hernández, Enrique González-Madrid, Pablo A González, Susan M Bueno, Alexis M Kalergis |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 55261 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |