Associations of neighborhood deprivation with breast cancer tumor genomics, targeted treatment use, and survival
Emily L. Podany, Lorenzo Foffano, Lorenzo Gerratana, Arielle J. Medford, Natalie K. Heater, Eleonora Nicolò, Shaili Tapiavala, Letizia Pontolillo, Annika Putur, Diana A. Jaber, Katherine Clifton, Nitin Katakam, Sarah Addison, Marla Lipsyc-Sharf, Carolina Reduzzi, Foluso O. Ademuyiwa, Fabio Puglisi, · 2026
Read Associations of neighborhood deprivation with breast cancer tumor genomics, targeted treatment use, and survival by Emily L. Podany, Lorenzo Foffano, Lorenzo Gerratana, Arielle J. Medford, Natalie K. Heater, Eleonora Nicolò, Shaili Tapiavala, Letizia Pontolillo, Annika Putur, Diana A. Jaber, Katherine Clifton, Nitin Katakam, Sarah Addison, Marla Lipsyc-Sharf, Carolina Reduzzi, Foluso O. Ademuyiwa, Fabio Puglisi, (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13534212.txt.
Description
Where a patient lives may shape even the genetics of her cancer. Emily Podany and co-authors study 1,127 patients with metastatic breast cancer at four United States centers. They compare tumor DNA, treatment received, and survival between patients from deprived neighborhoods and better-off ones, scored by a national deprivation index.
About 30 percent lived in high-deprivation areas. Their tumors more often carried TP53 mutations, a sign of aggressive disease. Among patients eligible for a targeted drug class, those from deprived areas received it far less often, about 17 versus 37 percent. Median survival was shorter too, 24 versus 28 months, and shortest for Black patients in deprived areas. The authors say place-based gaps reach from tumor biology to bedside care.
Catalog record
| CREATOR | Emily L. Podany, Lorenzo Foffano, Lorenzo Gerratana, Arielle J. Medford, Natalie K. Heater, Eleonora Nicolò, Shaili Tapiavala, Letizia Pontolillo, Annika Putur, Diana A. Jaber, Katherine Clifton, Nitin Katakam, Sarah Addison, Marla Lipsyc-Sharf, Carolina Reduzzi, Foluso O. Ademuyiwa, Fabio Puglisi, |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 36 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |