Exercise elicits mitonuclear protein imbalance and UPRmt in the liver of mice with obesity
Matheus Biscaro Rocha, Izabela Monteiro de Araujo, Saulo Gabriel do Nascimento Della Coleta, Scylas J. A. Junior, Sidney F. Peres, Renata R. Braga, Rafael S. Brícola, Fernanda S. Carneiro, Barbara M. Crisol, Raul G. da Costa, Marcelo A. S. Mori, Dennys E. Cintra, Adelino S. R. da Silva, José R. Paul · 2026
Read Exercise elicits mitonuclear protein imbalance and UPRmt in the liver of mice with obesity by Matheus Biscaro Rocha, Izabela Monteiro de Araujo, Saulo Gabriel do Nascimento Della Coleta, Scylas J. A. Junior, Sidney F. Peres, Renata R. Braga, Rafael S. Brícola, Fernanda S. Carneiro, Barbara M. Crisol, Raul G. da Costa, Marcelo A. S. Mori, Dennys E. Cintra, Adelino S. R. da Silva, José R. Paul (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13534197.txt.
Description
Matheus Biscaro Rocha and co-authors study how exercise changes liver mitochondria in obese mice, in a 2026 paper. Faulty mitochondria help drive fatty liver disease. A stress response inside mitochondria, called the unfolded protein response, may restore their function, but whether exercise switches it on in the liver was unknown.
Data from a panel of mouse strains first showed that genes of that response ran low when liver fat ran high, in both mice and humans. Four weeks of aerobic training then strongly shifted liver metabolism in fat-fed mice and stopped fat build-up. Exercise raised a protein imbalance between the nucleus and mitochondria, raised markers of the stress response, and improved mitochondrial housekeeping and function. The authors link that chain to how exercise prevents fatty liver disease.
Catalog record
| CREATOR | Matheus Biscaro Rocha, Izabela Monteiro de Araujo, Saulo Gabriel do Nascimento Della Coleta, Scylas J. A. Junior, Sidney F. Peres, Renata R. Braga, Rafael S. Brícola, Fernanda S. Carneiro, Barbara M. Crisol, Raul G. da Costa, Marcelo A. S. Mori, Dennys E. Cintra, Adelino S. R. da Silva, José R. Paul |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 43 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |