Health effects associated with alcohol consumption: a Burden of Proof study
Xiaochen Dai, Sneha I. Nicholson, Hilary R. Lawlor, Sinclair Carr, Jaimie D. Steinmetz, Natalie M. Chen, Susan A. McLaughlin, Simon I. Hay, Kanyin L. Ong, Aleksandr Y. Aravkin, Peng Zheng, Reed J. D. Sorensen, Nora M. Gilbertson, Erin C. Mullany, Erin M. O’Connell, Christopher J. L. Murray, Emmanuel · 2026
Read Health effects associated with alcohol consumption: a Burden of Proof study by Xiaochen Dai, Sneha I. Nicholson, Hilary R. Lawlor, Sinclair Carr, Jaimie D. Steinmetz, Natalie M. Chen, Susan A. McLaughlin, Simon I. Hay, Kanyin L. Ong, Aleksandr Y. Aravkin, Peng Zheng, Reed J. D. Sorensen, Nora M. Gilbertson, Erin C. Mullany, Erin M. O’Connell, Christopher J. L. Murray, Emmanuel (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13533843.txt.
Description
Xiaochen Dai and colleagues re-examined alcohol's health effects with a conservative, cross-outcome method. Published in 2026, the Burden of Proof study ran sixteen systematic reviews across four databases, re-analyzing 843 cohort and case-control studies for twenty health outcomes. Drinking guidelines differ widely, leaving drinkers unsure what intake, if any, counts as safe.
Current drinking tracked higher risks for ten cancers plus pancreatitis, cirrhosis and other liver disease, lung infections, tuberculosis, and atrial fibrillation. For type 2 diabetes, dementia, and several heart and stroke outcomes, risks dipped at low-to-moderate intake before rising, forming J- or U-shaped curves. High intake raised risk across every outcome. The authors offer a single comparable evidence base for guidelines, with observational limits acknowledged.
Catalog record
| CREATOR | Xiaochen Dai, Sneha I. Nicholson, Hilary R. Lawlor, Sinclair Carr, Jaimie D. Steinmetz, Natalie M. Chen, Susan A. McLaughlin, Simon I. Hay, Kanyin L. Ong, Aleksandr Y. Aravkin, Peng Zheng, Reed J. D. Sorensen, Nora M. Gilbertson, Erin C. Mullany, Erin M. O’Connell, Christopher J. L. Murray, Emmanuel |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 67 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |