Age‐Associated Four‐Gene Prognostic Signature in Breast Cancer
Shiro Uchida · 2026
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Description
Shiro Uchida searches for a gene pattern that explains why breast cancer that starts young tends to come back sooner. His 2026 paper mines data from a large cancer atlas covering 821 patients with early-stage disease, 142 of them aged forty-five or under. Young patients indeed fared worse on time without disease return.
Screening tied four genes to both age and disease return. A score built from those genes stayed linked to worse outcomes even after standard factors were counted. Once the score entered the model, the age effect itself faded. Tumors with high scores showed more cell growth and repair activity. In a second data set the score predicted return overall, but not within the young group alone. Uchida calls the pattern a lead that needs fresh testing.
Catalog record
| CREATOR | Shiro Uchida |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |