The dark genome in cardiovascular medicine
Despoina Kesidou, Simon D Brown, Lars Maegdefessel, Igor Ulitsky, Andrew H Baker · 2026
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Description
Despoina Kesidou and co-authors review the dark genome and its role in heart and vessel medicine, in this 2026 paper. Only about one to two percent of human DNA codes for proteins. The rest, long dismissed, holds switches, repeated stretches, and genes for non-coding RNA. These parts steer gene activity, cell identity, and disease risk.
The review covers the dark genome parts tied to cardiovascular disease. Non-coding RNAs get special focus, since their control roles are coming into focus. New genome tools have sharpened the links between these regions and heart traits. The authors argue that growing insight opens paths to targeted drugs for prevention and care. They stress that much of the map is still being drawn.
Catalog record
| CREATOR | Despoina Kesidou, Simon D Brown, Lars Maegdefessel, Igor Ulitsky, Andrew H Baker |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 52 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |