MSCs overexpressing FGF21 alleviate acetaminophen-induced acute liver injury by eliciting macrophage-mediated phagocytosis
Qian Huai, Cheng Zhu, Haoran Huang, Long Cheng, Xiaoqin Deng, Yue Wang, Tianyin Sun, Lijuan Mao, Yongkang Zhang, Mengwei Wu, Shi Yin, Hanren Dai, Xiaolei Li, Hua Wang · 2026
Read MSCs overexpressing FGF21 alleviate acetaminophen-induced acute liver injury by eliciting macrophage-mediated phagocytosis by Qian Huai, Cheng Zhu, Haoran Huang, Long Cheng, Xiaoqin Deng, Yue Wang, Tianyin Sun, Lijuan Mao, Yongkang Zhang, Mengwei Wu, Shi Yin, Hanren Dai, Xiaolei Li, Hua Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13533497.txt.
Description
Huai leads a large team testing engineered stem cells for liver injury, in work from twenty twenty-six. The injury comes from acetaminophen, a common pain and fever drug that harms the liver when misused. Stem cells from marrow type tissue show promise, but their effect could be stronger.
The team altered the cells to make extra FGF21, a hormone that guides energy use and helps cells home to injury. They tested whether the boosted cells protect the liver better. The proposed path works through macrophages, immune cells that clear dead tissue. If the boost holds up, engineered cells could become a stronger therapy for acute drug induced liver harm.
Catalog record
| CREATOR | Qian Huai, Cheng Zhu, Haoran Huang, Long Cheng, Xiaoqin Deng, Yue Wang, Tianyin Sun, Lijuan Mao, Yongkang Zhang, Mengwei Wu, Shi Yin, Hanren Dai, Xiaolei Li, Hua Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |