Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes
Elisa Gomez-Gil, Paolo Guerra, Ying Gu, Sherman Foo, Benedicte Billard, Gabor Balogh, Maria Peter, Snezhana Oliferenko · 2026
Read Adaptation of eukaryotic membrane homeostasis to species-specific cellular lipid landscapes by Elisa Gomez-Gil, Paolo Guerra, Ying Gu, Sherman Foo, Benedicte Billard, Gabor Balogh, Maria Peter, Snezhana Oliferenko (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13532661.txt.
Description
Cell membranes must keep their fat mix within a range that lets the cell work, and each species tunes its control system to its own mix. An eight-author team compared two related fission yeasts whose membrane fats differ, focusing on a sensor protein called Mga2 that switches on a fat-modifying enzyme gene when membranes grow too saturated.
The sensor's trigger point sits at different saturation levels in the two species, matched to each one's normal state. Swapping a short stretch near the sensor's membrane anchor shifted its behavior, showing that this small region fine-tunes the response. In one species, the target gene also starts from a higher baseline, set by its own control region, which supports a more unsaturated membrane overall. The team offers the case as a general lesson in how homeostatic circuits evolve.
Catalog record
| CREATOR | Elisa Gomez-Gil, Paolo Guerra, Ying Gu, Sherman Foo, Benedicte Billard, Gabor Balogh, Maria Peter, Snezhana Oliferenko |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 77 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |