The crucial role of RIG-I in upregulating neutrophil CXCR2 expression through the MAPK signaling pathway in viral pneumonia
Yuxin Wang, Qi Shi, Yaxin Pan, Xiaoyu Sun, Huayang Wang, Yi Zhang · 2026
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Description
Yuxin Wang and colleagues trace in 2026 how a viral sensor inside cells summons neutrophils into COVID-19 lungs. Blood from 66 patients and 31 healthy controls was tracked for neutrophil share and a homing receptor called CXCR2. Severe patients carried more neutrophils with higher receptor levels, tied to worse outlook and higher inflammatory signals.
A viral mimic switched on the sensor RIG-I in lung and blood cells, raising receptor levels through a MAPK relay and drawing neutrophils in. Blocking the sensor, the relay, or the receptor eased lung injury in mice, nominating a drug chain.
Catalog record
| CREATOR | Yuxin Wang, Qi Shi, Yaxin Pan, Xiaoyu Sun, Huayang Wang, Yi Zhang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 71291 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |