Microbial DNA analysis of paired blood-bronchoalveolar lavage fluid in post-HSCT patients with pneumonia implying application conditions of blood as a surrogate in pathogen detection
Ruiqi Li, Xiangyan He, Zhonglin Chen, Jie Shao, Jiangzhou Feng, Liping Wan, Mengyuan Zhang, Jun Yang, Yin Tong, Baoxia Dong, Chongmei Huang, Huiying Qiu, Yu Cai, Jiahua Niu, Xiaowei Xu, Xianming Song, Jinmin Ma, Hongfeng Ge, Kun Zhou · 2026
Read Microbial DNA analysis of paired blood-bronchoalveolar lavage fluid in post-HSCT patients with pneumonia implying application conditions of blood as a surrogate in pathogen detection by Ruiqi Li, Xiangyan He, Zhonglin Chen, Jie Shao, Jiangzhou Feng, Liping Wan, Mengyuan Zhang, Jun Yang, Yin Tong, Baoxia Dong, Chongmei Huang, Huiying Qiu, Yu Cai, Jiahua Niu, Xiaowei Xu, Xianming Song, Jinmin Ma, Hongfeng Ge, Kun Zhou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13531842.txt.
Description
Ruiqi Li and co-authors ask in 2026 when a blood test can stand in for lung wash fluid when hunting pneumonia germs after stem cell transplant. Paired samples from transplant patients and healthy-immune patients underwent DNA sequencing, with a larger transplant group used to validate markers. Lung sampling is invasive, so a blood shortcut would help fragile patients.
Microbe patterns differed sharply between blood and lung fluid only in transplant patients, whose lung fluid carried richer growth. Far more blood sequences matched lung sequences in that group, tied to leakier lung barriers. Hundreds of blood sequences predicted lung presence with over 70 percent certainty.
Catalog record
| CREATOR | Ruiqi Li, Xiangyan He, Zhonglin Chen, Jie Shao, Jiangzhou Feng, Liping Wan, Mengyuan Zhang, Jun Yang, Yin Tong, Baoxia Dong, Chongmei Huang, Huiying Qiu, Yu Cai, Jiahua Niu, Xiaowei Xu, Xianming Song, Jinmin Ma, Hongfeng Ge, Kun Zhou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49471 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |