Targeting LRPPRC to improve corneal wound healing via augmenting autophagy and suppressing TGF-β/Smad signaling post-alkali burn
Bolin Chen, Huizhuo Xu, Bowen Li, Yingjun Cai, Lihui Xie, Jing Zou · 2026
Read Targeting LRPPRC to improve corneal wound healing via augmenting autophagy and suppressing TGF-β/Smad signaling post-alkali burn by Bolin Chen, Huizhuo Xu, Bowen Li, Yingjun Cai, Lihui Xie, Jing Zou (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13531831.txt.
Description
Bolin Chen and colleagues target in 2026 a protein that blocks cell cleanup and worsens scarring after chemical burns to the eye surface. Alkali burns trigger a growth pathway that overproduces scar material and clouds the cornea. A mouse burn model tracked the blocker protein LRPPRC over time and tested silencing it.
Burned corneas swelled, grew new vessels, and showed rising blocker levels by day 14. Gene silencing or inhibitor eye drops eased swelling and vessel growth, revived cleanup proteins, and quieted the scarring pathway. Human corneal cells in dishes responded the same way, supporting drop development.
Catalog record
| CREATOR | Bolin Chen, Huizhuo Xu, Bowen Li, Yingjun Cai, Lihui Xie, Jing Zou |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 56840 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |