Bacteria-derived glutarate mitigates Alzheimer’s disease model pathology through autophagy-lysosomal pathway
Cui Deng, Mingqin Qu, Wei Yao, Xiaotong Hu, Yan Li, Weilun Zheng, Yiying Zhai, Fangyan Liu, Ting Yang, Tianlong Wang, Xiangming Wang · 2026
Read Bacteria-derived glutarate mitigates Alzheimer’s disease model pathology through autophagy-lysosomal pathway by Cui Deng, Mingqin Qu, Wei Yao, Xiaotong Hu, Yan Li, Weilun Zheng, Yiying Zhai, Fangyan Liu, Ting Yang, Tianlong Wang, Xiangming Wang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13531758.txt.
Description
Cui Deng and co-authors trace in 2026 how a gut bacterium product eases Alzheimer-like damage in tiny worms. The E. coli strain HB101 improved learning, slowed nerve loss, and delayed paralysis in worm models of the disease. Chemical screening singled out glutarate, a small molecule the bacteria release, as a key active product.
Glutarate switched on the cell cleanup system centered on lysosomes and self-digestion, clearing clumps of the harmful amyloid protein. Stress-response pathways inside cell power stations and protein factories also woke up. The work points from gut microbes toward a candidate molecule for future therapy research.
Catalog record
| CREATOR | Cui Deng, Mingqin Qu, Wei Yao, Xiaotong Hu, Yan Li, Weilun Zheng, Yiying Zhai, Fangyan Liu, Ting Yang, Tianlong Wang, Xiangming Wang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 62478 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |