Durynes G-I, antiproliferative polyacetylenes from Cribrochalina vasculum and their chlorinated decomposition products
Lucero Martinez-Fructuoso, Susan Ensel, Rhone K. Akee, Brian D. Peyser, John R. Britt, Jason R. Evans, Barry R. O'Keefe, Tanja Grkovic · 2026
Read Durynes G-I, antiproliferative polyacetylenes from Cribrochalina vasculum and their chlorinated decomposition products by Lucero Martinez-Fructuoso, Susan Ensel, Rhone K. Akee, Brian D. Peyser, John R. Britt, Jason R. Evans, Barry R. O'Keefe, Tanja Grkovic (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13531520.txt.
Description
Lucero Martinez-Fructuoso and co-authors (2026) report three new natural compounds from the sea sponge Cribrochalina vasculum. Guided by cell-killing tests, the team separated the sponge extract and isolated three members of the duryne family, durynes G, H, and I. They worked out the structures with spectroscopy and set the handedness of one key carbon with a chemical method. The compounds proved unstable in a common solvent, slowly turning into chlorinated versions of themselves.
The team solved the structures of those breakdown products too and proposed how the chlorine atoms get added. In a standard panel of sixty human cancer cell lines, the three new compounds slowed cell growth at low doses. Adding chlorine to the middle of the chain weakened the activity, and chlorine near the alcohol end weakened it further. The study adds new chemistry and a warning about storing this compound family.
Catalog record
| CREATOR | Lucero Martinez-Fructuoso, Susan Ensel, Rhone K. Akee, Brian D. Peyser, John R. Britt, Jason R. Evans, Barry R. O'Keefe, Tanja Grkovic |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |