Synthesis, X-ray structures and biological evaluation of novel α-aminophosphonate derivatives as anti-inflammatory and antioxidant agents: an integrated in vitro and in silico study
Zoubir Douib, Hacene K’tir, Haiet Douib, Zinelaabidine Cheraiet, Taha Khaldi, Latifa Khattabi, Brahim Harkati, Vincent Dorcet, Fabrice Pointillart · 2026
Read Synthesis, X-ray structures and biological evaluation of novel α-aminophosphonate derivatives as anti-inflammatory and antioxidant agents: an integrated in vitro and in silico study by Zoubir Douib, Hacene K’tir, Haiet Douib, Zinelaabidine Cheraiet, Taha Khaldi, Latifa Khattabi, Brahim Harkati, Vincent Dorcet, Fabrice Pointillart (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13531417.txt.
Description
Zoubir Douib and eight co-authors craft new phosphorus compounds and test them against swelling and rust stress in a 2026 study. The family built pairs a known drug part with a numbing agent part in one pot reactions. Twenty two variants came out in fair to high yields, and X-ray crystal reads fixed their true shapes.
Several variants mopped up free radicals well in two bench tests, the richer in electron giving groups most of all. In a protein based swelling test, four led the pack. The best matched a standard drug's mark of near ninety eight percent. Mealworm larvae shrugged off the doses used, with deaths only at the top dose for the lead compound. Computer reads rounded out the electron picture behind the activity.
Catalog record
| CREATOR | Zoubir Douib, Hacene K’tir, Haiet Douib, Zinelaabidine Cheraiet, Taha Khaldi, Latifa Khattabi, Brahim Harkati, Vincent Dorcet, Fabrice Pointillart |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 70 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |