Physiology-Guided Closure of Iatrogenic Atrial Septal Defect After Paravalvular Leak Repair
Yusuke Samejima, Go Hashimoto, Yutsuki Tsukagoshi, Atsuhiro Saito, Sari Waga, Shiho Ide, Kenji Makino, Hiroki Niikura, Nobutaka Ikeda, Hidehiko Hara · 2026
Read Physiology-Guided Closure of Iatrogenic Atrial Septal Defect After Paravalvular Leak Repair by Yusuke Samejima, Go Hashimoto, Yutsuki Tsukagoshi, Atsuhiro Saito, Sari Waga, Shiho Ide, Kenji Makino, Hiroki Niikura, Nobutaka Ikeda, Hidehiko Hara (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13531199.txt.
Description
Samejima and colleagues described in 2026 a physiology-guided way to close a hole in the heart wall that was created by a prior procedure. The patient had developed severe low blood oxygen after a catheter procedure fixed a leak around a heart valve. That procedure had crossed the wall between the heart's upper chambers, leaving a defect that let blood shunt from right to left.
Samejima's team first used ultrasound imaging to confirm the shunt, then measured pressures between the chambers and the load on the lung vessels directly. They tried inhaled nitric oxide as a rescue step, mapped the defect in three dimensions, and then closed it urgently with a catheter device, after which the patient recovered. Their message is that closure choices should rest on how the heart is behaving, not on the defect's shape alone, since such a hole can sometimes relieve pressure.
Catalog record
| CREATOR | Yusuke Samejima, Go Hashimoto, Yutsuki Tsukagoshi, Atsuhiro Saito, Sari Waga, Shiho Ide, Kenji Makino, Hiroki Niikura, Nobutaka Ikeda, Hidehiko Hara |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 23 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |