Inhibition of Cyclin-dependent Kinase Counteracts Neuron-promoted Bladder and Endometrial Tumorigenesis: A Systematic Analysis
MIN-HONG WANG, MEI-REN PAN, YU-HSUAN HUNG · 2026
Read Inhibition of Cyclin-dependent Kinase Counteracts Neuron-promoted Bladder and Endometrial Tumorigenesis: A Systematic Analysis by MIN-HONG WANG, MEI-REN PAN, YU-HSUAN HUNG (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13531175.txt.
Description
Min-Hong Wang, Mei-Ren Pan, and Yu-Hsuan Hung published a systematic analysis in 2026 on whether blocking a cell-cycle enzyme can counter neuron-fed tumor growth. Neurons are a neglected part of the tumor surroundings. The team mined a neuro-cancer database across cancer types for neural activity, survival, immune links, and drug ties. Bladder, thyroid, and womb cancers stood out as nerve-influenced.
A drug screen flagged a kinase blocker as a candidate. In lab co-culture, neurons sped growth of bladder and womb cancer cells, and the blocker erased that boost. Spatial data showed neural activity highest in tumor cores. The authors back this drug class against neuron-supported growth.
Catalog record
| CREATOR | MIN-HONG WANG, MEI-REN PAN, YU-HSUAN HUNG |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 27 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |