Ramelteon Mitigates Cisplatin-induced Testicular Dysfunction in Rats
SHUN KAWAMURA, KOJI CHIBA, KAZUKI TSUBOTANI, CHANHYON KIN, YOSUKE YAMASHITA, KATSUYA SATO, KEISUKE OKADA, HIDEAKI MIYAKE · 2026
Read Ramelteon Mitigates Cisplatin-induced Testicular Dysfunction in Rats by SHUN KAWAMURA, KOJI CHIBA, KAZUKI TSUBOTANI, CHANHYON KIN, YOSUKE YAMASHITA, KATSUYA SATO, KEISUKE OKADA, HIDEAKI MIYAKE (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13531113.txt.
Description
Shun Kawamura and seven co-authors tested in 2026 whether a sleep drug can shield the testes of rats from a cancer drug's harm. The cancer drug, cisplatin, can impair sperm and hormone output, and few guards exist. The sleep drug acts on melatonin receptors and is known to protect organs from swelling and cell death. Thirty-two young male rats were split into four groups for a week of dosing.
Cisplatin alone damaged the sperm-making tubes, cut sperm count and movement, and lowered testosterone. Adding the sleep drug softened each of those harms and eased tissue damage. Gene activity for hormone making recovered in part, while death and swelling signals fell. The authors propose the drug as a candidate for guarding fertility during chemotherapy.
Catalog record
| CREATOR | SHUN KAWAMURA, KOJI CHIBA, KAZUKI TSUBOTANI, CHANHYON KIN, YOSUKE YAMASHITA, KATSUYA SATO, KEISUKE OKADA, HIDEAKI MIYAKE |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 25 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |