Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate
Erik Storrs, Chia-Kuei Mo, Wen-hung Chou, Gaurav Bhatt, Siqi Chen, Xiyi Wei, Andrew Houston, Alla Karpova, Reyka G. Jayasinghe, Preet Lal, Peter Bayguinov, John M. Herndon, Xiang Li, Faria Anjum Simin, Xiangwei Fang, Michael C. Wendl, Xinhao Liu, Hongyu Zheng, Sherri R. Davies, Julia T. Wang, Andrew · 2026
Read Spatial Mapping of the Precancer-to-Cancer Transition in Breast and Prostate by Erik Storrs, Chia-Kuei Mo, Wen-hung Chou, Gaurav Bhatt, Siqi Chen, Xiyi Wei, Andrew Houston, Alla Karpova, Reyka G. Jayasinghe, Preet Lal, Peter Bayguinov, John M. Herndon, Xiang Li, Faria Anjum Simin, Xiangwei Fang, Michael C. Wendl, Xinhao Liu, Hongyu Zheng, Sherri R. Davies, Julia T. Wang, Andrew (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13531001.txt.
Description
Erik Storrs and a large team map the step where early breast and prostate growths turn into cancer, in a 2026 paper. Both cancers feed on hormones and break out of their ducts in like ways. The team first used light-sheet imaging on whole tumors to find the seams where tame growth meets invading cells. They then built a workflow that stacks thin slices into 3D maps and reads gene activity by place.
The maps drew on 319 tests from 51 cases. In breast tumors, loss of two named genes marked the shift to invasion, and tests in cells backed their role. In prostate tumors, four genes rose along the path to invasion, and muting them slowed cell growth and movement. Immune cells also crowded along the breast seams, hinting they help drive the change.
Catalog record
| CREATOR | Erik Storrs, Chia-Kuei Mo, Wen-hung Chou, Gaurav Bhatt, Siqi Chen, Xiyi Wei, Andrew Houston, Alla Karpova, Reyka G. Jayasinghe, Preet Lal, Peter Bayguinov, John M. Herndon, Xiang Li, Faria Anjum Simin, Xiangwei Fang, Michael C. Wendl, Xinhao Liu, Hongyu Zheng, Sherri R. Davies, Julia T. Wang, Andrew |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 100 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |