Mechanism of lovastatin in promoting ferroptosis of prostate cancer cells by regulating the mevalonate pathway
Yanhong Xiao, Zhengdao Liu, Yougang Feng, Han Zhu, Bo Wang, Shulian Chen, Guobiao Liang · 2026
Read Mechanism of lovastatin in promoting ferroptosis of prostate cancer cells by regulating the mevalonate pathway by Yanhong Xiao, Zhengdao Liu, Yougang Feng, Han Zhu, Bo Wang, Shulian Chen, Guobiao Liang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13530939.txt.
Description
Yanhong Xiao and colleagues show in 2026 how the cholesterol drug lovastatin kills prostate cancer cells through an iron-driven death route called ferroptosis. Five statin drugs were screened on cancer cell lines, with lovastatin emerging strongest. Tests tracked growth, movement, invasion, iron levels, and cell power stations.
Lovastatin slowed all aggressive behaviors and raised iron and damaging oxygen species while altering death-linked proteins. An iron-blocking rescue drug reversed those effects. Feeding back the blocked pathway product restored cell survival and calmed stress markers. The results nominate the pathway-to-ferroptosis chain as a treatment target.
Catalog record
| CREATOR | Yanhong Xiao, Zhengdao Liu, Yougang Feng, Han Zhu, Bo Wang, Shulian Chen, Guobiao Liang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 41753 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |