Poster 245. Improving Rotator Cuff Repair With Tissue Engineering and Biotherapeutics
John M Tokish, Jose Iturregui, Cara Lai · 2026
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Description
Tokish, Iturregui, and Lai present in 2026, as conference poster 245, animal experiments on improving rotator cuff repair with bioengineered patches and biologic materials. The repairs were tested biomechanically, genetically, and under the microscope at eight weeks after surgery.
Four augmentations were compared against traditional repair, alongside sham controls in the rat model used for this work. They were an electrospun synthetic patch mimicking the tendon-to-bone junction, a sheet of amnion membrane from the placenta, and a combination of the two. Breaking strength ran higher on average in every patch group than in traditional repair, and the yield loads showed the same ordering. The combination patch's tissue maturity score matched traditional repair. However, the electrospun products provoked an exaggerated immune reaction with giant cells and fibrotic growth, a warning the authors say warrants further investigation before clinical enthusiasm.
Catalog record
| CREATOR | John M Tokish, Jose Iturregui, Cara Lai |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 3 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |