Genomic characterization of carbapenemase-producing Enterobacterales from wastewater reveals the convergence of KPC-2 and GES-16 in Brazil
João Pedro Rueda Furlan, Giovanna Carrasco Bueno, Rubens Renato Sousa-Carmo, Renan Lourenço Oliveira Silva, Mikaela Renata Funada Barbosa, Maria Ines Zanoli Sato, Nilton Lincopan, Sergio Schenkman · 2026
Read Genomic characterization of carbapenemase-producing Enterobacterales from wastewater reveals the convergence of KPC-2 and GES-16 in Brazil by João Pedro Rueda Furlan, Giovanna Carrasco Bueno, Rubens Renato Sousa-Carmo, Renan Lourenço Oliveira Silva, Mikaela Renata Funada Barbosa, Maria Ines Zanoli Sato, Nilton Lincopan, Sergio Schenkman (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13529879.txt.
Description
Joao Pedro Rueda Furlan and co-authors track drug-proof bacteria in sewage in Brazil, focusing on microbes that resist carbapenems, a last-line drug class. Wastewater plants can act as pools where such germs and their genes gather and trade. The team reads the full genomes of strains pulled from raw plant inflow.
Drug tests showed wide resistance, spanning carbapenems and polymyxins, in Klebsiella and Enterobacter strains. Genome reads found two key resistance genes, KPC-2 and GES-16, meeting in the same strains, with GES-5 also present. The KPC-2 gene sat inside jumping DNA segments that help it spread. Some strains matched high-risk clones known from hospitals. The findings warn that sewage can merge rare resistance traits into harder-to-treat forms.
Catalog record
| CREATOR | João Pedro Rueda Furlan, Giovanna Carrasco Bueno, Rubens Renato Sousa-Carmo, Renan Lourenço Oliveira Silva, Mikaela Renata Funada Barbosa, Maria Ines Zanoli Sato, Nilton Lincopan, Sergio Schenkman |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 31 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |