Vagus nerve–dependent antidepressant effects of ineupatorolide B via gut microbiota modulation in a mouse model of depression
Siming Wang, Yuqian Zhang, Ningning Wu, Siqi Wang, Yuhe Ma, Weichen Zhang, Guiying Li, Kenji Hashimoto, Zhiyu Ni · 2026
Read Vagus nerve–dependent antidepressant effects of ineupatorolide B via gut microbiota modulation in a mouse model of depression by Siming Wang, Yuqian Zhang, Ningning Wu, Siqi Wang, Yuhe Ma, Weichen Zhang, Guiying Li, Kenji Hashimoto, Zhiyu Ni (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13529800.txt.
Description
Siming Wang and eight colleagues test a plant compound against depression-like behavior in mice in a 2026 study. The compound, ineupatorolide B, comes from a medicinal herb family. Mice were stressed by repeated social defeat. Treated mice got the compound, a standard antidepressant, or plain vehicle. Behavior, blood inflammation, and brain synapse proteins were all measured.
The compound reversed the stress effects across the board. Inflammation signals fell and synapse markers in the prefrontal cortex recovered. Gut microbe diversity, knocked off balance by stress, largely normalized. Helpful short-chain fatty acids returned. Cutting the vagus nerve erased every benefit. That proves the gut-to-brain nerve route carries the effect, the authors argue. They propose the compound as a microbe-targeted depression candidate. Human relevance needs far more work.
Catalog record
| CREATOR | Siming Wang, Yuqian Zhang, Ningning Wu, Siqi Wang, Yuhe Ma, Weichen Zhang, Guiying Li, Kenji Hashimoto, Zhiyu Ni |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 49257 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |