PER2 reprograms intracellular cholesterol synthesis to inhibit oral squamous cell carcinoma and the chronotherapeutic efficacy of simvastatin
Shilin Yin, Fang Yang, Zhiwei Zhang, Mingyuan Liu, Hong Tang, Kai Yang · 2026
Read PER2 reprograms intracellular cholesterol synthesis to inhibit oral squamous cell carcinoma and the chronotherapeutic efficacy of simvastatin by Shilin Yin, Fang Yang, Zhiwei Zhang, Mingyuan Liu, Hong Tang, Kai Yang (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13529778.txt.
Description
Shilin Yin and five colleagues tie a body clock gene to cholesterol making in mouth cancer in a 2026 study. The gene, PER2, runs daily rhythms. It was scarce in oral squamous cancers. Low PER2 let cells make more cholesterol and grow faster. Restoring it did the reverse. The team traced the chain link by link.
PER2 grabs a structural protein, MYH9, and recruits a disposal tagger. MYH9 then gets destroyed, which throttles the rate-limiting cholesterol enzyme. In mouse tumors, extra PER2 or the statin simvastatin each slowed growth. Together they worked far better. Daily rhythms in the pathway differed by sex in mice. The statin's power swung up to two and a half fold by dosing hour. Timed dosing windows were wider in females. The authors propose clock-aware statin pairing.
Catalog record
| CREATOR | Shilin Yin, Fang Yang, Zhiwei Zhang, Mingyuan Liu, Hong Tang, Kai Yang |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 72060 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |