Uncovering the potential anti-cancer compounds from Strobilanthes cusia against colorectal cancer through network pharmacology and molecular docking
Yogananthan Dhanapal, Duraisamy Sridhar, Sulekha Khute, Paranthaman Subash · 2026
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Description
Yogananthan Dhanapal and three colleagues test a medicinal herb against colorectal cancer in a 2026 study. The plant, Strobilanthes cusia, is a folk remedy for inflammation. Leaf extracts were made with four solvents in sequence. The alcohol extract killed two colon cancer cell lines best. Chemical scans found thirteen active ingredients.
One compound, andrographolide, was isolated from this plant for the first time. Network analysis pointed to a cell cycle guard, CHEK1, as its main target. Computer docking showed the compound gripping CHEK1 as well as a reference drug. Simulated motion kept the grip stable. Dish tests confirmed dose-driven cell death and slower growth. The authors back deeper study of the plant compound. Animal work would be the honest next step.
Catalog record
| CREATOR | Yogananthan Dhanapal, Duraisamy Sridhar, Sulekha Khute, Paranthaman Subash |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 80692 |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |