Identification of a Novel Small Molecule Facilitating HIV Elimination by the “Shock‐And‐Kill” Approach
Yuichiro Hara, Haruki Kitamura, Kouki Matsuda, Chieko Fujisaki, Sayaka Sukegawa, Kosuke Tanimoto, Kenji Maeda, Hiroaki Takeuchi · 2026
Read Identification of a Novel Small Molecule Facilitating HIV Elimination by the “Shock‐And‐Kill” Approach by Yuichiro Hara, Haruki Kitamura, Kouki Matsuda, Chieko Fujisaki, Sayaka Sukegawa, Kosuke Tanimoto, Kenji Maeda, Hiroaki Takeuchi (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13529267.txt.
Description
Yuichiro Hara and seven co-authors hunt for an HIV cure compound in a 2026 paper. Modern therapy controls the virus but cannot clear hidden reservoirs of infected cells. A shock-and-kill strategy wakes the virus so the cells can be destroyed. Most known waking agents only shock, without the kill. Screening a small-molecule library turned up a compound that seems to do both.
The compound reactivated hidden virus and selectively harmed the reservoir cell lines. At single-cell level the two effects looked independent, so one did not simply cause the other. It also switched on viral activity in cells taken from treated patients. More validation in primary cells is urged.
Catalog record
| CREATOR | Yuichiro Hara, Haruki Kitamura, Kouki Matsuda, Chieko Fujisaki, Sayaka Sukegawa, Kosuke Tanimoto, Kenji Maeda, Hiroaki Takeuchi |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |