S14G‐humanin attenuates renal ischaemia–reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats
Leyla Abueid, Ahmet Faruk Torun, Ezgi Golal, Nuray Acar, Filiz Basrali · 2026
Read S14G‐humanin attenuates renal ischaemia–reperfusion injury, potentially through activation of STAT3 and ERK1/2 signalling pathways in rats by Leyla Abueid, Ahmet Faruk Torun, Ezgi Golal, Nuray Acar, Filiz Basrali (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13529252.txt.
Description
Leyla Abueid and co-authors test, in twenty twenty-six, whether a modified mitochondrial peptide protects rat kidneys from ischemia-reperfusion injury. That injury follows restored blood flow after a cutoff, and can cause acute kidney failure. The peptide, S14G-humanin, is known for anti-death and anti-inflammatory effects. Forty-eight male rats were split into four groups: sham surgery, injury alone, peptide with sham, and peptide with injury. In injury groups, the kidney artery was clamped for forty-five minutes, then released for a day. The peptide was given minutes before reperfusion.
Injury raised kidney stress markers and cut antioxidant defenses. The peptide restored glutathione and a key enzyme, and lowered two damage markers. It also raised cell energy and mitochondrial function, though two kidney function markers were unchanged.
Catalog record
| CREATOR | Leyla Abueid, Ahmet Faruk Torun, Ezgi Golal, Nuray Acar, Filiz Basrali |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 44 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |