Mitophagy in neuronal health and disease: from mechanisms to neurodegeneration
Bishal Basak, Julia F. Riley, Neha M. Nataraj, Erika L.F. Holzbaur · 2026
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Description
Bishal Basak and co-authors review how neurons take out their mitochondrial trash in a 2026 paper. Mitophagy, selective eating of worn mitochondria, guards nerve cells that cannot dilute damage by dividing. Its failure is tied to Parkinson's disease and ALS.
The review maps the routes: a damage-sensing pathway built on PINK1 and Parkin, plus receptor-led routes that tag mitochondria directly. Routine turnover at synapses and axon tips runs even without damage. When clearance fails, inflammation pathways wake, including two named alarm systems. Gene, tissue, and lab evidence all point the same way. Fixing the cleanup is a drug target class the authors endorse.
Catalog record
| CREATOR | Bishal Basak, Julia F. Riley, Neha M. Nataraj, Erika L.F. Holzbaur |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 46 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |