Retraction of TREM2 aggravates sepsis by inhibiting fatty acid oxidation via the SHP1/BTK axis
Siqi Ming, Xingyu Li, Qiang Xiao, Siying Qu, Qiaohua Wang, Qiongyan Fang, Pingping Liang, Yating Xu, Jingwen Yang, Yongqiang Yang, Xi Huang, Yongjian Wu · 2026
Read Retraction of TREM2 aggravates sepsis by inhibiting fatty acid oxidation via the SHP1/BTK axis by Siqi Ming, Xingyu Li, Qiang Xiao, Siying Qu, Qiaohua Wang, Qiongyan Fang, Pingping Liang, Yating Xu, Jingwen Yang, Yongqiang Yang, Xi Huang, Yongjian Wu (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13528936.txt.
Description
Siqi Ming and co-authors have their 2025 sepsis paper retracted in 2026, and this notice explains why in full. The original study claimed a protein called TREM2 worsens sepsis by blocking fat burning in immune cells through a named signaling path. The claim rested in part on fat burning rates shown in two figure panels.
The authors later found those rates were wrong: the data had not been scaled to the amount of protein in each sample. Once scaled properly, the drugs used in the study no longer rescued fat burning in cells lacking the protein. Since those figures carried the paper's key findings, the authors asked the journal to retract the article and apologized for the errors. The notice stands as the record that the original conclusions should not be relied on.
Catalog record
| CREATOR | Siqi Ming, Xingyu Li, Qiang Xiao, Siying Qu, Qiaohua Wang, Qiongyan Fang, Pingping Liang, Yating Xu, Jingwen Yang, Yongqiang Yang, Xi Huang, Yongjian Wu |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 2 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |