Gut microbial trimethylamine N-oxide generation promotes risk of atrial fibrillation via muscarinic receptor–mediated autonomic dysfunction
Selvam Arjunan, Isaiah Pemberton, Xinmin S. Li, Naseer Sangwan, Lydia Akino, Emmanuel Opoku, Dmitriy Verbovetskiy, Ina Nemet, Hyun Su Kim, Haruko Masumiya, Zeneng Wang, Joseph A. Lupica, Melissa Y. Tian, Karis Mao, Deepthi P. Mallela, Maradumane L. Mohan, Sarah M. Schumacher, Julie H. Rennison, Sathyamangla V. Naga Prasad, Kenneth R. Laurita, Vamsi Chodisetty, Mina K. Chung, David R. Van Wagoner, John Barnard, Jonathan D. Smith, Oussama Wazni, Stanley L. Hazen, Robert A. Koeth · 2026
Read Gut microbial trimethylamine N-oxide generation promotes risk of atrial fibrillation via muscarinic receptor–mediated autonomic dysfunction by Selvam Arjunan, Isaiah Pemberton, Xinmin S. Li, Naseer Sangwan, Lydia Akino, Emmanuel Opoku, Dmitriy Verbovetskiy, Ina Nemet, Hyun Su Kim, Haruko Masumiya, Zeneng Wang, Joseph A. Lupica, Melissa Y. Tian, Karis Mao, Deepthi P. Mallela, Maradumane L. Mohan, Sarah M. Schumacher, Julie H. Rennison, Sathyamangla V. Naga Prasad, Kenneth R. Laurita, Vamsi Chodisetty, Mina K. Chung, David R. Van Wagoner, John Barnard, Jonathan D. Smith, Oussama Wazni, Stanley L. Hazen, Robert A. Koeth (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/PMC13528925.txt.
Description
Selvam Arjunan leads a large team tying a gut-made chemical to atrial fibrillation in a 2026 study. The chemical, TMAO, forms when gut microbes process foods like choline. Blood levels were measured in people having heart catheter tests. Higher levels tracked with having the rhythm disorder, even after risk factors were counted. Mouse work then tested cause.
Mice prone to the disorder developed it sooner on a TMAO diet. Normal mice showed more inducible episodes too. Extra choline sped onset, while a blocker that cuts TMAO slowed it. Gut microbe mixes shifted with choline and partly normalized with the blocker. Hearts remodeled badly, with wider left atria and slower electrical spread. TMAO jammed a muscarinic receptor, skewing nerve control of the heart. The authors name the pathway a drug target.
Catalog record
| CREATOR | Selvam Arjunan, Isaiah Pemberton, Xinmin S. Li, Naseer Sangwan, Lydia Akino, Emmanuel Opoku, Dmitriy Verbovetskiy, Ina Nemet, Hyun Su Kim, Haruko Masumiya, Zeneng Wang, Joseph A. Lupica, Melissa Y. Tian, Karis Mao, Deepthi P. Mallela, Maradumane L. Mohan, Sarah M. Schumacher, Julie H. Rennison, Sathyamangla V. Naga Prasad, Kenneth R. Laurita, Vamsi Chodisetty, Mina K. Chung, David R. Van Wagoner, John Barnard, Jonathan D. Smith, Oussama Wazni, Stanley L. Hazen, Robert A. Koeth |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 50 KB |
| LICENSE | https://creativecommons.org/licenses/by/4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |