Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease
Artur Shvetcov, Shannon Thomson, Mark E Graham, Brittany Hauger, Jessica E Keller, Christine J Smoyer, Sarah E Tague, Ann‐Na Cho, Farhad B Imam, Varsha Krish, Global Neurodegeneration Proteomics Consortium (GNPC), Matthew K Taylor, Jonathan D Mahnken, Debra K Sullivan, Joanne H Reed, Jeffrey M Burns · 2026
Read Cross‐tissue immune profiling of APOE ε4 reveals early dysregulation in Alzheimer's disease by Artur Shvetcov, Shannon Thomson, Mark E Graham, Brittany Hauger, Jessica E Keller, Christine J Smoyer, Sarah E Tague, Ann‐Na Cho, Farhad B Imam, Varsha Krish, Global Neurodegeneration Proteomics Consortium (GNPC), Matthew K Taylor, Jonathan D Mahnken, Debra K Sullivan, Joanne H Reed, Jeffrey M Burns (2026) in the Tower of Babel, a free online library of public-domain works preserved in clean, searchable text. No sign-up. The full text is served as a plain-text file at a predictable URL, where text is present: https://antarctic-labs.com/tower-of-babel/pmc-13528450.txt.
Description
Carrying the APOE ε4 gene variant is the strongest known genetic risk for late-onset Alzheimer's disease, but how it drives the disease is unclear. Artur Shvetcov and a large consortium team profiled immune proteins across body tissues in 2026 to find the variant's early fingerprint.
The team combined protein data from blood, spinal fluid, and two brain regions, covering thousands of donors. Carriers showed a shared pro-inflammatory protein pattern that grew stronger with each copy of the variant, whether or not they had Alzheimer's. Brain-like organoids grown from patient cells showed the same pattern before any plaques appeared. A twelve-week ketogenic diet partly reversed the pattern, hinting at an early target for prevention.
Catalog record
| CREATOR | Artur Shvetcov, Shannon Thomson, Mark E Graham, Brittany Hauger, Jessica E Keller, Christine J Smoyer, Sarah E Tague, Ann‐Na Cho, Farhad B Imam, Varsha Krish, Global Neurodegeneration Proteomics Consortium (GNPC), Matthew K Taylor, Jonathan D Mahnken, Debra K Sullivan, Joanne H Reed, Jeffrey M Burns |
|---|---|
| YEAR | 2026 |
| COLLECTION | PAPERS |
| FORMAT | TXT |
| FILE SIZE | 81 KB |
| VERSION | 1.0 |
| LICENSE | CC BY 4.0 |
| RIGHTS | CC BY |
| SOURCE | Europe PMC |